Article Publish Status: FREE
Abstract Title:

The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease.

Abstract Source:

Biomedicines. 2021 Jul 22 ;9(8). Epub 2021 Jul 22. PMID: 34440065

Abstract Author(s):

Mireia Urpi-Sarda, Rosa Casas, Emilio Sacanella, Dolores Corella, Cristina Andrés-Lacueva, Rafael Llorach, Gloria Garrabou, Francesc Cardellach, Aleix Sala-Vila, Emilio Ros, Miguel Ruiz-Canela, Montserrat Fitó, Jordi Salas-Salvadó, Ramon Estruch

Article Affiliation:

Mireia Urpi-Sarda


The intervention with the Mediterranean diet (MD) pattern has evidenced short-term anti-inflammatory effects, but little is known about its long-term anti-inflammatory properties at molecular level. This study aims to investigate the 3-year effect of MD interventions compared to low-fat diet (LFD) on changes on inflammatory biomarkers related to atherosclerosis in a free-living population with a high-risk of cardiovascular disease (CD). Participants (= 285) in the PREDIMED trial were randomly assigned into three intervention groups: MD with extra-virgin olive oil (EVOO) or MD-Nuts, and a LFD. Fourteen plasma inflammatory biomarkers were determined by Luminex assays. An additional pilot study of gene expression (GE) was determined by RT-PCR in 35 participants. After 3 years, both MDs showed a significant reduction in the plasma levels of IL-1β, IL-6, IL-8, TNF-α, IFN-γ, hs-CRP, MCP-1, MIP-1β, RANTES, and ENA78 (<0.05; all). The decreased levels of IL-1β, IL-6, IL-8, and TNF-α after MD significantly differed from those in the LFD (<0.05). No significant changes were observed at the gene level after MD interventions, however, the GE of CXCR2 and CXCR3 tended to increase in the control LFD group (= 0.09). This study supports the implementation of MD as a healthy long-term dietary pattern in the prevention of CD in populations at high cardiovascular risk.

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