Active ingredients ofL. exhibits similar anti-cancer effects as isoalantolactone in pancreatic cancer cells.
Nat Prod Res. 2020 Sep ;34(17):2539-2544. Epub 2019 Jan 19. PMID: 30661396
Y Y Yan
Isoalantolactone is one of the major active ingredients fromL. However, it is low cost-effective to isolate isoalantolactone fromL. In this study, we optimized the extraction strategy and obtained a mixture of active ingredients with exact proportion (termed as), which were alloalantolactone, alantolactone and isoalantolactone at the ratio of 1/5/4 respectively. The anti-tumor activity ofwas compared with isoalantolactone on pancreatic cancer cells. As a result,showed nearly the same anti-proliferation activity as isoalantolactone in two cell lines. Bothand isoalantolactone could induce mitochondrion-related apoptosis at the concentration of 6 μg/ml. In addition,inhibited colony-formation and migration of PANC-1 and SW1990 cells. To conclude,exhibited similar anti-proliferation and anti-migration effect as isoalantolactone on two pancreatic cancer cell lines, suggesting that alantolactone or alloalantolactone might have comparable anti-tumor effect as isoalantolactone.