n/a
Abstract Title:

Antiproliferative effect of secofriedelanophyllemblicine, a triterpenoid present in the roots ofL.

Abstract Source:

Nat Prod Res. 2021 Sep 13:1-5. Epub 2021 Sep 13. PMID: 34514922

Abstract Author(s):

Cuifang Wang, Huaimeng Xu, Yixuan Wang

Article Affiliation:

Cuifang Wang

Abstract:

PL. is a widely distributed tropical medicinal plant with good therapeutic properties. In the present study, the chemical constituents isolation of the roots ofwere carried out and six known compounds (-) were purified and their structures were determined by means of spectroscopic analysis. The known triterpenoid, secofriedelanophyllemblicine (), was selected to check for its cytotoxic effect on a series of human tumor cells and normal cells. Secofriedelanophyllemblicine exhibited cell growth inhibition specifically on MCF-7 breast cancer cells when compared to other tested cell lines. Further flow cytometric analysis showed that secofriedelanophyllemblicine could inhibit cell proliferation and induced G2 phase arrest in the cell-cycle progression of MCF-7 cells. The gathered results suggest that secofriedelanophyllemblicine is a cell-cycle regulator in MCF-7 human breast cancer cells and might be used as a candidate chemopreventive agent for breast cancer prevention and intervention.

Study Type : In Vitro Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.