Antiviral effects of bovine lactoferrin on human norovirus. - GreenMedInfo Summary
Antiviral Effects of Bovine Lactoferrin on Human Norovirus.
Biochem Cell Biol. 2020 Apr 29. Epub 2020 Apr 29. PMID: 32348689
Human noroviruses cause significant morbidity and mortality worldwide but lack approved antivirals or vaccines to treat or prevent infections. The recent development of two cell culture systems in human transformed B cells (BJABs) and non-transformed human intestinal enteroids cultures overcomes a main limitation in identifying molecules with anti-norovirus activities. Lactoferrin is an iron-binding glycoprotein found in the milk of most mammals with broad spectrum antimicrobial activities, including against the related murine norovirus in cell culture. Its ingestion also reduced the incidence of infectious gastroenteritis in Japanese clinical trial participants. Since human noroviruses were the most common cause of gastroenteritis in Japan during the clinical trial period, we sought to determine whether lactoferrin can inhibit human norovirus infection. Our study demonstrates that lactoferrin reduces human norovirus infection in the B cell culture model. The mechanism of antiviral action is likely indirect and may involve induction of innate interferon responses. Therefore, future studies are warranted to test the antiviral efficacy of lactoferrin against human norovirus infection in patients.