Article Publish Status: FREE
Abstract Title:

Effect of Astaxanthin on the Expression and Activity of Aquaporin-3 in Skin in an In-Vitro Study.

Abstract Source:

Life (Basel). 2020 Sep 11 ;10(9). Epub 2020 Sep 11. PMID: 32932769

Abstract Author(s):

Nobutomo Ikarashi, Risako Kon, Chika Nagoya, Airi Ishikura, Yuri Sugiyama, Jiro Takahashi, Kiyoshi Sugiyama

Article Affiliation:

Nobutomo Ikarashi


Astaxanthin (3,3'-dihydroxy-β,β-carotene-4,4'-dione) is a red lipophilic pigment with strong antioxidant action. Oral or topical administration of astaxanthin has been reported to improve skin function, including increasing skin moisture. In this study, we examined the mechanism by which astaxanthin improves skin function byfocusing on the water channel aquaporin-3 (AQP3), which plays important roles in maintaining skin moisture and function. When astaxanthin was added to PHK16-0b or HaCaT cells, the mRNA expression level of AQP3 increased significantly in a concentration-dependent manner in both cell lines. The AQP3protein expression level was also confirmed to increase when astaxanthin was added to HaCaT cells. Similarly, when astaxanthin was added to 3D human epidermis model EpiSkin, AQP3 expression increased. Furthermore, when glycerol and astaxanthin were simultaneously added to EpiSkin, glycerol permeability increased significantly compared with that observed for the addition of glycerol alone. We demonstrated that astaxanthin increases AQP3 expression in the skin and enhances AQP3 activity. This result suggests that the increased AQP3 expression in the skin is associated with the increase in skin moisture by astaxanthin. Thus, we consider astaxanthin useful for treating dry skin caused by decreased AQP3 due to factors such as diabetes mellitus and aging.

Study Type : In Vitro Study

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