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Article Publish Status: FREE
Abstract Title:

Astragaloside IV: An Effective Drug for the Treatment of Cardiovascular Diseases.

Abstract Source:

Drug Des Devel Ther. 2020 ;14:3731-3746. Epub 2020 Sep 15. PMID: 32982178

Abstract Author(s):

Yu-Qing Tan, Heng-Wen Chen, Jun Li

Article Affiliation:

Yu-Qing Tan

Abstract:

Cardiovascular disease (CVD), the number one cause of death worldwide, has always been the focus of clinical and scientific research. Due to the high number of deaths each year, it is essential to find alternative therapies that are safe and effective with minimal side effects. Traditional Chinese medicine (TCM) has a long history of significant impact on the treatment of CVDs. The mode of action of natural active ingredients of drugs and the development of new drugs are currently hot topics in research on TCM.is a commonly used Chinese medicinal herb. Previous studies have shown thathas anti-tumor properties and can regulate metabolism, enhance immunity, and strengthen the heart. Astragaloside IV (AS-IV) is the active ingredient of, which has a prominent role in cardiovascular diseases. AS-IV can protect against ischemic and hypoxic myocardial cell injury, inhibit myocardial hypertrophy and myocardial fibrosis, enhance myocardial contractility, improve diastolic dysfunction, alleviate vascular endothelial dysfunction, and promote angiogenesis. It can also regulate blood glucose and blood lipid levels and reduce the risk of cardiovascular diseases. In this paper, the mechanism of AS-IV intervention in cardiovascular diseases in recent years is reviewed in order to provide a reference for future research and new drug development.

Study Type : Review

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