Biomedical effects of. leaf extract on vital organs in streptozotocin-induced diabetic rats: Experimental research.
Ann Med Surg (Lond). 2021 Jan ;61:188-197. Epub 2020 Nov 21. PMID: 33520200
Rebin Rafaat Mohammed
Diabetes mellitus (DM) has been treated with herbs for centuries and many herbs reported to exert antidiabetic activity.is an aromatic herb belonging to thefamily, commonly known as bay. This study aimed to investigate the activity ofleave extracts on histopathological and biochemical changes inβ-cells of streptozotocin (STZ)-induced diabetic rats. Thirty healthy adult male albino rats were included in the study and divided equally into 5 groups for 4 weeks as follow; control group (C), diabetic group (D), diabeticextract group (DLN),extract group (LN) and diabetic acarbose (DA) group. Histopathologically, D group rats exhibited various degenerative and necrotic changes in their liver, pancreas and kidney, whereas the DLN rats had nearly normal histology. Insulin immunostaining in the pancreatic beta cells was decreased in the D group compared to the C group, whereas the DLN group was similar to the C group. The glucose concentration decreased significantly in both diabetic rats treated withand acarbose ( < 0.05). Additionally, the levels of aspartate aminotransferase (AST), gamma-glutamyltransferase (GGT) and alanine aminotransferase (ALT) enzyme were significantly decreased in both diabetic rats treated withand acarbose, compared to the D group (˃ 0.05). Outcomes of this study said that leave extracts ofhas valuable effect on blood glucose level and ameliorative effect on regeneration of pancreatic islets, it also restored the altered liver enzymes, urea, creatine kinase, total protein levels, calcium and ferritin to near normal.