Abstract Title:

Bisphenol A decreases progesterone synthesis in human ovarian granulosa cells.

Abstract Source:

Birth Defects Res. 2020 Oct 19. Epub 2020 Oct 19. PMID: 33073540

Abstract Author(s):

Junfeng Qi, Lida Liu, Jie Yang, Xueying Gao, Wei Zhang

Article Affiliation:

Junfeng Qi


Evidences indicate that the decline of female fertility is becoming a common problem over the past few decades. Environmental exposure of Bisphenol A (BPA) has been considered as an endocrine-disrupting chemical deleteriously affecting human reproductions. To better understand the effect of BPA exposure on human ovarian granulosa cells, we treated human ovarian granulosa cell line (KGN) with increasing concentrations (0.1, 1, 10, and 100 μM) of BPA for 24 hr. About 0.1, 1, and 10 μM BPA did not significantly affect the viability of KGN while 100 μM of BPA caused a statistically significant decrease in the viability of KGN. Treatment KGN with 10 μM BPA resulted in a significant decrease in progesterone biosynthesis. The treatment also significantly increased the expression of ATP binding cassette subfamily A member 1 (ABCA1) and steroidogenic acute regulatory protein (STAR). In the current study, exposure to BPA could lead to decreased progesterone production probably through the upregulation of ABCA1 in human granulosa cells.

Study Type : In Vitro Study

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Sayer Ji
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