Cirsimaritin may be the active anti-allergic component in C. maritimum Makino. - GreenMedInfo Summary
Cirsium maritimum Makino Inhibits the Antigen/Immunoglobulin-E-Mediated Allergic Response In Vitro and In Vivo.
J Agric Food Chem. 2017 Sep 27 ;65(38):8386-8391. Epub 2017 Sep 19. PMID: 28876919
We investigated whether Cirsium maritimum Makino can inhibit immunoglobulin-E-mediated allergic response in rat basophilic leukemia (RBL-2H3) cells and passive cutaneous anaphylaxis (PCA) in BALB/c mice. In vitro, the ethyl acetate extract of C. maritimum Makino (ECMM) significantly inhibitedβ-hexosaminidase release and decreased intracellular Calevels in RBL-2H3 cells. Moreover, ECMM leaves more strongly suppressed the release ofβ-hexosaminidase than ECMM flowers. ECMM leaves also significantly suppressed the PCA reaction in the murine model. High-performance liquid chromatography andH andC nuclear magnetic resonance indicated that cirsimaritin, a flavonoid, was concentrated in active fractions of the extract. Our findings suggest that ECMM leaves have a potential regulatory effect on allergic reactions that may be mediated by mast cells. Furthermore, cirsimaritin may be the active anti-allergic component in C. maritimum Makino.