Article Publish Status: FREE
Abstract Title:

Depsides: Lichen Metabolites Active against Hepatitis C Virus.

Abstract Source:

PLoS One. 2015 ;10(3):e0120405. Epub 2015 Mar 20. PMID: 25793970

Abstract Author(s):

Thi Huyen Vu, Anne-Cécile Le Lamer, Claudia Lalli, Joël Boustie, Michel Samson, Françoise Lohézic-Le Dévéhat, Jacques Le Seyec

Article Affiliation:

Thi Huyen Vu


A thorough phytochemical study of Stereocaulon evolutum was conducted, for the isolation of structurally related atranorin derivatives. Indeed, pilot experiments suggested that atranorin (1), the main metabolite of this lichen, would interfere with the lifecycle of hepatitis C virus (HCV). Eight compounds, including one reported for the first time (2), were isolated and characterized. Two analogs (5, 6) were also synthesized, to enlarge the panel of atranorin-related structures. Most of these compounds were active against HCV, with a half-maximal inhibitory concentration of about 10 to 70µM, with depsides more potent than monoaromatic phenols. The most effective inhibitors (1, 5 and 6) were then added at different steps of the HCV lifecycle. Interestingly, atranorin (1), bearing an aldehyde function at C-3, inhibited only viral entry, whereas the synthetic compounds 5 and 6, bearing a hydroxymethyl and a methyl function, respectively, at C-3 interfered with viral replication.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antiviral Agents : CK(1957) : AC(1034)

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