Curcumin ameliorates aflatoxin-induced changes in SDH and ATPase activities in liver and kidney of mice.
Acta Pol Pharm. 2008 Jul-Aug;65(4):415-9. PMID: 19051581
Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad 380 009, GUJ., India. firstname.lastname@example.org
The present investigation was an attempt to evaluate the ameliorative effect of curcumin on aflatoxin-induced changes in activities of succinate dehydrogenase (SDH) and adenosine triphosphatase (ATPase) in liver and kidney of mice. Aflatoxin was obtained by growing Aspergillus parasiticus in SMKY liquid medium. Pure curcumin (97% purity) was purchased from Hi-Media Laboratories Pvt. Ltd., Mumbai, India. Young adult male albino mice were orally administered with low dose and high dose (750 and 1500 microg/kg body weight) aflatoxin with and without curcumin (2 mg/0.2 mLolive oil/animal/day) for 45 days. On 46th day the animals were sacrificed by cervical dislocation and organs were removed to prepare homogenates for measuring changes in enzyme activities such as succinate dehydrogenase and adenosine triphosphatase. The results showed that in liver and kidney of mice activities of both the enzymes succinate dehydrogenase and adenosine triphosphatase were found to be reduced in the groups treated with low dose and high dose of aflatoxin, which were ameliorated by the treatment of curcumin along with aflatoxin in other groups. Thus, curcumin along with aflatoxin ameliorates aflatoxin-induced changes in succinate dehydrogenase and adenosine triphosphatase activities in liver and kidney of mice.