Abstract Title:

Curcumin inhibits nitrite-induced methemoglobin formation.

Abstract Source:

FEBS Lett. 1992 Apr 20;301(2):195-6. PMID: 1314741

Abstract Author(s):

M K Unnikrishnan, M N Rao

Article Affiliation:

Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Manipal, India.


Curcumin protects hemoglobin from nitrite-induced oxidation to methemoglobin. The protection is not observed when curcumin is added after the autocatalytic stage of the oxidation of hemoglobin by nitrite. The ability of curcumin to scavenge superoxide may be responsible since superoxide is implicated in promoting the autocatalytic stage of oxidation of hemoglobin by nitrite.

Study Type : In Vitro Study

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