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Abstract Title:

The diverse bioactivity ofα-mangostin and its therapeutic implications.

Abstract Source:

Future Med Chem. 2021 Aug 19. Epub 2021 Aug 19. PMID: 34410182

Abstract Author(s):

Tejashri Chavan, Aaron Muth

Article Affiliation:

Tejashri Chavan

Abstract:

α-Mangostin is a xanthone natural product isolated as a secondary metabolite from the mangosteen tree. It has attracted a great deal of attention due to its wide-ranging effects on certain biological activity, such as apoptosis, tumorigenesis, proliferation, metastasis, inflammation, oxidation, bacterial growth and metabolism. This review focuses on the key pathways directly affected by α-mangostin and how this varies between disease states. Insight is also provided, where investigated, into the key structural features of α-mangostin that produce these biological effects. The review thensheds light on the utility of α-mangostin as a investigational tool for certain diseases and demonstrate how future derivatives may increase selectivity and potency for specific disease states.

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