Article Publish Status: FREE
Abstract Title:

Eriodictyol as a Potential Candidate Inhibitor of Sortase A Protects Mice From Methicillin-Resistant-Induced Pneumonia.

Abstract Source:

Front Microbiol. 2021 ;12:635710. Epub 2021 Feb 18. PMID: 33679670

Abstract Author(s):

Li Wang, Qianxue Li, Jiaxin Li, Shisong Jing, Yajing Jin, Lin Yang, Hangqian Yu, Dacheng Wang, Tiedong Wang, Lin Wang

Article Affiliation:

Li Wang


New anti-infective approaches are urgently needed to control multidrug-resistant (MDR) pathogens, such as methicillin-resistant(MRSA). Sortase A (SrtA) is a membrane-bound cysteine transpeptidase that plays an essential role in the catalysis of covalent anchoring of surface proteins to the cell wall of(). The present study reports identification of a flavonoid, eriodictyol, as a reversible inhibitor of SrtA with an ICof 2.229± 0.014 μg/mL that can be used as an innovative means to counter both resistance and virulence. The data indicated that eriodictyol inhibited the adhesion of the bacteria to fibrinogen and reduced the formation of biofilms and anchoring of staphylococcal protein A (SpA) on the cell wall. The results of fluorescence quenching experiments demonstrated a strong interaction between eriodictyol and SrtA. Subsequent mechanistic studies revealed that eriodictyol binds to SrtA by interacting with R197 amino acid residue. Importantly, eriodictyol reduced the adhesion-dependent invasion of A549 cellsbyand showed a good therapeutic effect in a model of mouse pneumonia induced by. Overall, the results indicated that eriodictyol can attenuate MRSA virulence and prevent the development of resistance by inhibiting SrtA, suggesting that eriodictyol may be a promising lead compound for the control of MRSA infections.

Study Type : Animal Study

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