Ferulic acid attenuates arsenic induced cardiotoxicity. - GreenMedInfo Summary
Ferulic acid attenuates arsenic induced cardiotoxicity in rats.
Biotechnol Appl Biochem. 2019 Oct 4. Epub 2019 Oct 4. PMID: 31584213
Arsenic (As), a potent environmental toxin causes cardiac functional impairments. Ferulic acid (FA), a ubiquitous dietary hydroxycinnamate exerts beneficial effects on human health. Hence, the present study investigated the effect of FA on myocardial oxidative stress parameters, ATP level, the status of cardiac cytoskeleton intermediate filaments - desmin, vimentin and AMPK signaling proteins in As intoxicated rats. Wistar rats were administered orally with FA-40 mg/kg and As-5 mg/kg alone and in combination for 30 days. Myocardial As content, serum cardiac marker enzyme activities including creatine kinase-isoenzyme, lactate dehydrogenase, and aspartate aminotransferase were increased in As exposed rats. An accumulation of myocardial oxidants such as reactive oxygen species, lipid peroxidation, nitric oxide, protein carbonyl content, and histological aberrations was observed. A significant decrease of myocardial antioxidants comprises superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione, and ascorbic acid and declined expression of desmin, vimentin was noted. Impaired energy signaling molecules AMPKα (Thr172), AMPKβ1 (Ser108), ACC (Ser79) and intracellular myocardial ATP depletion were observed in As intoxicated animals. FA attenuates As induced cardiac dysfunction by restoring the expression of intermediate filaments and AMPK proteins. Based on the above findings, FA treatment could be usedas a novel therapeutic against As induced cardiac dysfunction. This article is protected by copyright. All rights reserved.