Article Publish Status: FREE
Abstract Title:

Glycerosome ofL. Essential Oil for Effective Anti-HSV Type 1.

Abstract Source:

Molecules. 2020 Jul 8 ;25(14). Epub 2020 Jul 8. PMID: 32650414

Abstract Author(s):

Giulia Vanti, Sotirios G Ntallis, Christos A Panagiotidis, Virginia Dourdouni, Christina Patsoura, Maria Camilla Bergonzi, Diamanto Lazari, Anna Rita Bilia

Article Affiliation:

Giulia Vanti


Essential oils are complex mixtures of strongly active compounds, very volatile and sensitive to light, oxygen, moisture and temperature. Loading inside nanocarriers can be a strategy to increase their stability and successfully use them in therapy. In the present study, a commercialL. (Lamiaceae) essential oil (MEO) was analyzed by gas chromatography-mass spectrometry, loaded inside glycerosomes (MEO-GS) and evaluated for its anti-herpetic activity against HSV type 1. MEO-GS analyses were prepared by the thin layer evaporation method and they were characterized by light scattering techniques, determining average diameter, polydispersity index andζ-potential. By transmission electron microscopy, MEO-GS appeared as small nano-sized vesicles with a spherical shape. MEO encapsulation efficiency inside glycerosomes, in terms of citral and β-caryophyllene, was found to be ca. 63% and 76% respectively, and MEO release from glycerosomes, performed by dialysis bag method, resulted in less than 10% within 24h. In addition, MEO-GS had high chemical and physical stability during 4 months of storage. Finally, MEO-GS were very active in inhibiting HSV type 1 infection of mammalian cells in vitro, without producing cytotoxic effects. Thus, MEO-GScould be a promising tool in order to provide a suitable anti-herpetic formulation.

Study Type : In Vitro Study

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