Abstract Title:

Hypoglycemic effect of hawthorn in type II diabetes mellitus rat model.

Abstract Source:

J Sci Food Agric. 2017 Mar 23. Epub 2017 Mar 23. PMID: 28337770

Abstract Author(s):

Aili Aierken, Tina Buchholz, Chen Chen, Xiaoying Zhang, Matthias F Melzig

Article Affiliation:

Aili Aierken


BACKGROUND: Hawthorn is one of the popular herbs in many different traditional medicine systems including in Traditional Chinese Medicine (TCM), where it has long been used for the treatment of hyperglycemia. However, most of its varied biological activities are still remaining unexplored. This study investigated the hypoglycemic effect of hawthorn extracts in type II diabetic (T2DM) rat model. A total of 54 rats were randomly divided into six groups. Normal control group (NC), type II diabetic model group (T2DM, T2DM rats were induced by high fat diet and streptozotocin), high, middle and low concentrations of hawthorn treat groups (HTH , HTM and HTL , T2DM rats were given hawthorn extract at the dose of 50, 100 and 200 mg kg ^-1.b.w, respectively) and positive control group (orlistat 40 mg kg ^-1.b.w, ORL).

RESULTS: showed that triglyceride (TG) and total cholesterol (TC) serum levels were decreased in the hawthorn extract treated groups than in the T2DM control group (P < 0.01). Furthermore, hawthorn extracts decreased blood glucose level and increased plasma insulin release from pancreas.

CONCLUSION: which demonstrates the positive effects of hawthorn against STZ-induced T2DM, this study suggests that hawthorn extract represents a useful agent for the prevention or treatment of T2DM.

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Sayer Ji
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