High doses of atorvastatin (Sortis) modify the secretory process in the exocrine portion of the pancreas.
Ann Univ Mariae Curie Sklodowska Med. 2004 ;59(2):52-6. PMID: 16146048
Department and Institute of Histology and Embryology, Skubiszewski Medical University of Lublin.
Changes were observed in the ultrastructure of the pancreatic acinar cells in rats after administration of atorvastatin (Sortis) in the therapeutic and ten times larger dose for the period of 6 weeks. It was found that atorvastatin given to rats in the therapeutic dose (80 mg/day) stimulated the secretion in pancreocytes, whereas the ten times higher dose of atorvastatin distorts the complicated process of the release of the secretion from the cell.