Article Publish Status: FREE
Abstract Title:

Honey and Chamomile Activate Keratinocyte Antioxidative Responses via the KEAP1/NRF2 System.

Abstract Source:

Clin Cosmet Investig Dermatol. 2020 ;13:657-660. Epub 2020 Sep 7. PMID: 32982358

Abstract Author(s):

Tatsuya Ogawa, Yosuke Ishitsuka, Yoshiyuki Nakamura, Naoko Okiyama, Rei Watanabe, Yasuhiro Fujisawa, Manabu Fujimoto

Article Affiliation:

Tatsuya Ogawa


Introduction: The stratum corneum protects against the entry of pathogens, allergens, and irritants while preventing dehydration. The Kelch-like erythroid cell-derived protein with cap-n-collar homology-associated protein 1 (KEAP1)/NF-E2-related factor 2 (NRF2) system maintains skin barrier homeostasis. Aggregated evidence suggests that NRF2-mediated antioxidative response is hardwired into the stratified squamous epithelia. Honey and chamomile have long been regarded as natural antioxidants. Nonetheless, it is still unclear whether they activate the KEAP1/NRF2 system in the epidermis and could promote epidermal barrier recovery.

Methods: To address the abovementioned issue, we explored the antioxidative property of honey/chamomile extract by using non-cell-based KEAP1-inhibition assay and cultured human epidermal keratinocytes.

Results: Herein we report that the extract inhibited KEAP1-NRF2 interaction and induced keratinocyte production of antioxidant small proline-rich protein.

Conclusion: Our results may offer an opportunity to develop cosmetic products that boost NRF2-mediated antioxidative/antiaging, epidermis-intrinsic bio-responses.

Study Type : In Vitro Study

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Sayer Ji
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