Article Publish Status: FREE
Abstract Title:

Basal and Spasmolytic Effects of a Hydroethanolic Leaf Extract ofL. on Intestinal Motility: AnStudy.

Abstract Source:

J Med Food. 2019 Jul ;22(7):653-662. Epub 2019 Apr 16. PMID: 30990736

Abstract Author(s):

Philippe Aubert, Isabelle Guinobert, Claude Blondeau, Valérie Bardot, Isabelle Ripoche, Pierre Chalard, Michel Neunlist

Article Affiliation:

Philippe Aubert


L. (lemon balm) has been used for decades with symptomatic benefits in patients with digestive disorders. However, very little is known on the effects ofon the gastrointestinal (GI) tract. In this study, the basal and spasmolytic properties of a hydroethanolic leaf extract (HLE) ofwere assessedon different segments of the GI tract of mice after phytochemical characterization of the extract.HLE had site- and dose-dependent effects on the contractile activity of the GI tract, the motility response being impacted in the jejunum and ileum but not in the antrum and colon. The observed effects could be caused by the phenolic compounds (mainly rosmarinic acid) detected in the extract.

Study Type : Human In Vitro
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