Abstract Title:

Lupeol suppresses migration and invasionp38/MAPK and PI3K/Akt signaling pathways in human osteosarcoma U-2 OS cells.

Abstract Source:

Biosci Biotechnol Biochem. 2019 Sep ;83(9):1729-1739. Epub 2019 Apr 22. PMID: 31010399

Abstract Author(s):

Ming-Jie Hsu, Shu-Fen Peng, Fu-Shin Chueh, Chang-Hai Tsai, Fuu-Jen Tsai, Chih-Yang Huang, Chih-Hsin Tang, Jai-Sing Yang, Yuan-Man Hsu, Wen-Wen Huang, Jing-Gung Chung

Article Affiliation:

Ming-Jie Hsu


Lupeol, one of the common components from the fruits and natural foods, has been reported to exert antitumor activities in many human cancer cell lines; however, its effects on osteosarcoma cell metastasis were not elucidated. In the present study, lupeol at 10-25μM induced cell morphological changes and decreased total viable cell number in U-2 OS cells. Lupeol (5-15 μM) suppressed cell mobility, migration, and invasion by wound healing and transwell chamber assays, respectively. Lupeol inhibited the activities of MMP-2 and -9 in U-2 OS cells by gelatin zymography assay. Lupeol significantly decreased PI3K, pAKT, β-catenin, and increased GSK3β. Furthermore, lupeol decreased the expressions of Ras, p-Raf-1, p-p38, and β-catenin. Lupeol also decreased uPA, MMP-2, MMP-9, and N-cadherin but increased VE-cadherin in U-2 OS cells. Based on these observations, we suggest that lupeol can be used in anti-metastasis of human osteosarcoma cells in the future.

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