Abstract Title:

Effect of adding the herb Achillea millefolium on mouthwash on chemotherapy induced oral mucositis in cancer patients: A double-blind randomized controlled trial.

Abstract Source:

Eur J Oncol Nurs. 2015 Jun ;19(3):207-13. Epub 2015 Feb 7. PMID: 25667123

Abstract Author(s):

Sedigheh Miranzadeh, Mohsen Adib-Hajbaghery, Leyla Soleymanpoor, Majid Ehsani

Article Affiliation:

Sedigheh Miranzadeh


BACKGROUND: Oral mucositis (OM) is a debilitating side-effect of chemotherapy. It has different complications, including impairment of drinking, eating and even talking, sometimes so severe that physician stops the therapy.

OBJECTIVE: Investigating the effect of Achillea millefolium distillate solution in the treatment of chemotherapy-induced OM.

INTERVENTIONS/METHODS: In this randomized controlled trial, 56 cancer patients with chemotherapy-induced OM were randomly assigned into control and experimental groups in similar blocks based on the severity of OM. The experimental group gargled 15 mL of a mixture of routine solution and distilled A. millefolium 4 times a day for 14 days while the control group gargled 15 mL of routine solution. The severity of OM was assessed at three times before, 7 and 14 days after intervention. Data was analyzed using Wilcoxon, Kruskal-Wallis, Mann-Whitney U, Friedman, Chi-square and Fisher's exact tests.

RESULTS: The mean severity score of OM was 2.39± 0.875 in both groups at start of the study that was changed to 1.07 ± 0.85 and 0.32 ± 0.54 in the intervention group in days 7 and 14 (p<0.001). However, the severity of OM was increased to 2.75± 0.87 and 2.89 ± 0.956 in the control group respectively (p<0.001).

CONCLUSIONS: A. millefolium distillate healed OM much more than the routine solution. Therefore, it is suggested to be used in patients with chemotherapy-induced OM. The study was registered in the Iranian Registry of Clinical Trials, Number: IRCT2013092214729N1.

Study Type : Human Study

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