Natural alkaloid harmine promotes degradation of alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation.
Phytomedicine. 2019 Aug ;61:152842. Epub 2019 Jan 30. PMID: 31048127
BACKGROUND: Parkinson's disease (PD) is an age-dependent progressive movement disorder characterized by a profound and selective loss of nigrostriatal dopaminergic neurons. Accumulation of
PURPOSE: This study aims to identify neuroprotective compounds which can alleviate the accumulation of
METHODS: High throughput screening was performed by dot blot assay. The degradation of different forms of
RESULTS: Through the high throughput screening, harmine was identified as a potent
CONCLUSION: Harmine, as a new proteasome enhancer, may have potential to be developed into therapeutic agent against neurodegenerative diseases associated with UPS dysfunction and aberrant proteins accumulation.