n/a
Abstract Title:

Novel Insight into Potential Leishmanicidal Activities of Transdermal Patches of: Formulation Development, Physical Characterizations, and/Assays.

Abstract Source:

Assay Drug Dev Technol. 2021 Jun 28. Epub 2021 Jun 28. PMID: 34182792

Abstract Author(s):

Barkat Ali Khan, Yasmin Asmat, Tariq Hayat Khan, Mughal Qayum, Sultan M Alshahrani, Muhammad Khalid Khan

Article Affiliation:

Barkat Ali Khan

Abstract:

Cutaneous Leishmaniasis (CL) is the most common type of Leishmaniasis, which annually affects 1.5 million people worldwide. About 90% of cases are reported from countries such as Iran, Afghanistan, Pakistan, Iraq, and Saudi Arabia. The purpose of the present study was to fabricate transdermal patches of(NS), characterize, and to check itsanti-activity. Hydroalcoholic extract was analyzed for preliminary phytochemicals. Five formulations of transdermal patches (NS1, NS2, NS3, NS4, and NS5) were prepared by solvent evaporation method. The optimized formulation NS5 was characterized for Fourier transform-infrared spectroscopy (FTIR), smoothness, brittleness, clarity, thickness, folding endurance, uniformity of weight, percent moisture content,drug release, release kinetics,drug permeation, andactivity.activity was assessed in 30 patients ( = 30) suffering from CL. The FTIR studies showed no incompatibility among the active extract and polymers.assay was 194.6% ± 1.88% as compared with standard drug (>0.05) andactivity was 75%. The drug release after 24 h was 87.0% ± 0.94% in NS5, which showed non-Fickian diffusion mechanism while drug permeation across rabbit skin after 24 h was up to 80.0% ± 0.91%. The results concluded that problems related to the parenteral medications used for Lieshmanial treatment can be managed by applying extract of NS seeds in the form of transdermal patch.

Study Type : Human Study, In Vitro Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.