Paraquat induced oxidative damage of the male reproductive system. - GreenMedInfo Summary
Oxidative damage of the male reproductive system induced by paraquat.
J Biochem Mol Toxicol. 2017 Mar ;31(3). Epub 2016 Oct 20. PMID: 27762473
The effects of paraquat (PQ) on the male reproductive system are unclear. In this study, male rats were divided into four groups (0, 0.5, 2, and 8 mg/kg) and treated with PQ by oral gavage for 8 weeks. At the end of the experiment, a significant decline in sperm count, motility, and viability and an increase in teratospermia were observed in the PQ-treated group (P<0.05). Further investigation found that PQ resulted in enhanced lipid peroxidation and more apoptosis in the testis tissues, and apoptosis was likely to be associated with activation of the mitochondrial pathway. In summary, our study demonstrated oxidative damage due to PQ on the male reproductive system.