Article Publish Status: FREE
Abstract Title:

L(amla) branch: A safe and effective ingredient against skin aging.

Abstract Source:

J Tradit Complement Med. 2021 Sep ;11(5):390-399. Epub 2021 Feb 9. PMID: 34522633

Abstract Author(s):

Puxvadee Chaikul, Mayuree Kanlayavattanakul, Jariya Somkumnerd, Nattaya Lourith

Article Affiliation:

Puxvadee Chaikul


Background and aim: Skin aging influences the changes in skin, including skin dryness, wrinkle, and irregular pigmentation. Amla (L.) branch has shown several benefits, but not the anti-skin aging. The study aimed to evaluate the anti-skin aging efficacy of amla branch.

Experimental procedure: Amla branches were standardized the phenolic acids. The extract was investigated anti-skin aging activities, including antioxidant, anti-tyrosinase, anti-melanogenesis, and matrix metalloproteinase-2 inhibitory assays. Topical gel containing extract was prepared and evaluated the skin irritation by a single closed patch test. Randomized, double-blind, placebo-control study was performed in 20 volunteers for 84 consecutive days. The tested skin was evaluated by Chromameter® CR 400, Dermalab® USB, Mexameter® MX 18, Corneometer® CM 825, and Visioscan® VC 98.

Results: Amla branch extract, a dark brown powder, consisted a variety of phenolic acids, mainly sinapic and ferulic acids. The extract exhibited the potent antioxidant and tyrosinase inhibitory activitiesassays and the melanin suppression through inhibition of tyrosinase and tyrosinase-related protein-2 activities, the strong antioxidant, and the potent matrix metalloproteinase-2 in cellular assays at 0.1 mg/mL. Topical gel containing 0.1% extract was a stable and safe formulation. Clinical study was proved the superior anti-skin aging efficacy, including the lightening skin color, the enhanced skin elasticity and hydration, and the skin wrinkle reduction.

Conclusion: The study results suggested that amla branch is a rich source of bioactive compounds and can be a potential ingredient for utilization in anti-skin aging products.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856)

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