Article Publish Status: FREE
Abstract Title:

Piperlongumine induces apoptosis and reduces bortezomib resistance by inhibiting STAT3 in multiple myeloma cells.

Abstract Source:

Oncotarget. 2016 Nov 8 ;7(45):73497-73508. PMID: 27634873

Abstract Author(s):

Yao Yao, Yueyue Sun, Min Shi, Dandan Xia, Kai Zhao, Lingyu Zeng, Ruosi Yao, Ying Zhang, Zhenyu Li, Mingshan Niu, Kailin Xu

Article Affiliation:

Yao Yao


Effective new therapies are urgently needed for the treatment of multiple myeloma (MM), an incurable hematological malignancy. In this study, we evaluated the effects of piperlongumine on MM cell proliferation both in vivo and in vitro. Piperlongumine inhibited the proliferation of MM cells by inducing cell apoptosis and blocking osteoclastogenesis. Notably, piperlongumine also reduced bortezomib resistance in MM cells. In a disseminated MM mouse model, piperlongumine prolonged the survival of tumor-bearing mice without causing any obvious toxicity. Mechanistically, piperlongumine inhibited the STAT3 signal pathway in MM cells by binding directly to the STAT3 Cys712 residue. These findings suggest that the clinical use of piperlongumine to overcome bortezomib resistance in MM should be evaluated.

Study Type : Animal Study, In Vitro Study

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Sayer Ji
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