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Abstract Title:

The Preventive Effect ofZS62 on DSS-Induced IBD by Regulating Oxidative Stress and the Immune Response.

Abstract Source:

Oxid Med Cell Longev. 2021 ;2021:9416794. Epub 2021 Oct 27. PMID: 34745426

Abstract Author(s):

Yanni Pan, Yujing Ning, Jing Hu, Zhiying Wang, Xiufeng Chen, Xin Zhao

Article Affiliation:

Yanni Pan

Abstract:

In this study, we used DSS to establish an IBD mouse model to study the preventive effect of() ZS62 on IBD in the context of oxidative stress and the immune response. We assessed the mitigating effect of this strain on IBD mice by examining the length of and histopathological changes in the colon, determining the serum antioxidant index and the levels of inflammatory cytokines, as well as the mRNA and protein expression levels of relevant genes. The study results showed thatZS62 could inhibit colonic atrophy in IBD mice, reduce the degree of colonic damage, downregulate the serum levels of MDA, MPO, IL-1, IL-6, IL-12, TNF-, and IFN-and the relative mRNA and protein expression of IL-1, IL-12, TNF-, COX-2, iNOS, and NF-B p65 in mouse colon tissues, and upregulate the serum levels of CAT, T-SOD, and IL-10 and the relative mRNA and protein expression of Cu/Zn SOD, Mn SOD, GSH-Px, CAT, IL-10, and IB-in colon tissues. In summary,ZS62 exhibited a good preventive effect on DSS-induced IBD by regulating oxidative stress and the immune response.

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