Abstract Title:

Protective effect of myricetin on LPS-induced mastitis in mice through ERK1/2 and p38 protein author.

Abstract Source:

Naunyn Schmiedebergs Arch Pharmacol. 2021 Aug ;394(8):1727-1735. Epub 2021 May 31. PMID: 34057544

Abstract Author(s):

Xingchi Kan, Juxiong Liu, Yingsheng Chen, Wenjin Guo, Dianwen Xu, Ji Cheng, Yu Cao, Zhanqing Yang, Shoupeng Fu

Article Affiliation:

Xingchi Kan


The inflammatory reaction of mammary gland tissue in dairy cattle leads to the occurrence of mastitis disease and causes huge economic loss. Myricetin (Myr), a flavonoid natural product, is extracted from the root, stem, and leaves of Myrica rubra. It has a wide range of biological activities, such as anti-oxidant, anti-inflammatory, and anti-tumor. The purpose of this experiment is to further explore the effect of Myr on mastitis and further explore its potential mechanism in LPS-induced mice mastitis model and LPS-induced mice mammary epithelial cells (mMECs). The results showed that Myr could significantly inhibit the expression of TNF-α, IL-6, and IL-1β in the mammary gland of mice. Furthermore, the results of mechanism studies show that Myr can significantly inhibit P38 and ERK1/2 protein phosphorylation levels in mice mammary tissue, and this result has been further verified at the cellular level. These results confirm that Myr can significantly inhibit mammary inflammation, and its potential mechanism is to play a protective role by inhibiting the phosphorylation level of P38 and ERK1/2 protein.

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