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Article Publish Status: FREE
Abstract Title:

Protective Effects of Baicalin on Arsenic Trioxide-induced Oxidative Damage and Apoptosis in Human Umbilical Vein Endothelial Cells.

Abstract Source:

In Vivo. 2021 Jan-Feb;35(1):155-162. PMID: 33402461

Abstract Author(s):

Chung-Lin Tsai, Chia-Wen Tsai, Wen-Shin Chang, Jiunn-Cherng Lin, Te-Chun Hsia, DA-Tian Bau

Article Affiliation:

Chung-Lin Tsai

Abstract:

BACKGROUND/AIM: Arsenic trioxide (AsO) is an environmental pollutant. However, the detailed mechanisms about AsO-induced loss of endothelial integrity are unknown. This study aimed at investigating how AsOcauses endothelial dysfunction and whether baicalin can reverse such dysfunction.

MATERIALS AND METHODS: Human umbilical vein endothelial cells (HUVECs) were used to examine AsO-induced oxidative stress, and apoptosis. The influence of baicalin on AsO-induced endothelial dysfunction were investigated.

RESULTS: The viability of HUVECs was inhibited by AsOand cells underwent apoptosis. AsOtreatment increased NADPH oxidase activity, and elevated the level of reactive oxygen species (ROS). Formamidopyrimidine DNA-glycosylase- and endonuclease III-digestible adducts were accumulated. Baicalin reversed AsO-induced apoptosis and AsO-suppressed cell viability. Baicalin caused a decrease in NADPH oxidase activity, and re-balanced the ROS level. AsO-induced formamidopyrimidine DNA-glycosylase- and endonuclease III-digestible adducts were down-regulated.

CONCLUSION: Baicalin was found to have the potential capacity to protect endothelial cells from AsO-induced cytotoxicity.

Study Type : In Vitro Study

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