Abstract Title:

Pulmonary Inflammatory Response from Co-exposure to LPS and Glyphosate.

Abstract Source:

Environ Toxicol Pharmacol. 2021 Mar 31:103651. Epub 2021 Mar 31. PMID: 33812014

Abstract Author(s):

Upkardeep Pandher, Shelley Kirychuk, David Schneberger, Brooke Thompson, Gurpreet Aulakh, R S Sethi, Baljit Singh

Article Affiliation:

Upkardeep Pandher


: Agricultural airborne work exposures are complex in nature and workplace exposures are a risk for respiratory outcomes in workers. Endotoxin and glyphosate are two common agents in agricultural exposures. While endotoxin (lipopolysaccaride, LPS) is a potent inflammatory agent it explains only a portion of the respiratory inflammatory response. The inflammatory potential when LPS is presented with another common agricultural respiratory agent, glyphosate, is not known.

METHODS: Mice were assigned to four treatment groups: control, LPS alone, glyphosate alone, glyphosate and LPS combined. Treatments were for 1, 5 or 10 days.

RESULTS: Five days of repeated exposure to the comintation of LPS and glyphosate resulted in higher neutrophil counts, myloperoxidase, TNF-α, IL-6, KC levels, and ICAM-1 and TLR-2 expression compared to the same length of treatment to LPS or glyphosate alone. After 10-days of exposure, inflammatory responses decreased, however leukocyte infiltration persisted along with increases in IL-4.

CONCLUSIONS: Glyphosate exposure modified LPS induced lung inflammatory responses and TLR-2 may be important in the modulated inflammatory response.

Study Type : In Vitro Study

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Sayer Ji
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