Red wine extract disrupts Th17 lymphocyte differentiation in a colorectal cancer context. - GreenMedInfo Summary
Red Wine Extract Disrupts Th17 Lymphocyte Differentiation in a Colorectal Cancer Context.
Mol Nutr Food Res. 2020 Apr 18:e1901286. Epub 2020 Apr 18. PMID: 32306526
SCOPE: It is well established that immune response and inflammation promote tumoral progression. Immune cells communicate through direct contact or through cytokine secretion, and it is the expression of these mediators and of the pro-inflammatory status that will tip the balance toward tumor progression or anti-tumor immunity. We have demonstrated that a red wine extract (RWE) was able to decrease inflammation through its action on the inflammasome complex. In this study, we sought to determine whether an RWE could impact other key actors of inflammation, in particular T helper 17 (Th17) immune cells.
METHODS AND RESULTS: Using an RWE containing 4.16 g of polyphenols/liter of wine, we showed that RWE decreased colorectal cancer cells (SW620, HCT116, MC38 and CT26) in vitro and that RWE induced a reduction in colorectal tumor growth associated with a decrease in tumor-infiltrating lymphocytes in vivo. The process of T-lymphocyte differentiation in Th17 cells was altered by RWE, as revealed by the decrease in the expression of key actors controlling this process, such as signal transducer and activator of transcription 3 and retinoid acid-related orphan receptorγt. This disruption was associated with an inhibition of inflammatory interleukin 17 secretion.
CONCLUSION: The data highlighted the major involvement of Th17 immune cells in the biological effects of an RWE. This article is protected by copyright. All rights reserved.