Abstract Title:

The role of diosgenin in diabetes and diabetic complications.

Abstract Source:

J Steroid Biochem Mol Biol. 2019 Dec 30 ;198:105575. Epub 2019 Dec 30. PMID: 31899316

Abstract Author(s):

Qingxia Gan, Jin Wang, Ju Hu, Guanhua Lou, Haijun Xiong, Chengyi Peng, Song Zheng, Qinwan Huang

Article Affiliation:

Qingxia Gan


Diabetes mellitus is a chronic and common metabolic disease that seriously endangers human health. Hyperglycemia and long-term metabolic disorders in diabetes will cause damage to the whole body tissues and organs, resulting in serious complications. Nowadays, drugs for treating diabetes on the market has strong side effects, new treatments thus are urgently needed. Natural therapy of natural ingredients is a promising avenue, this is because natural ingredients are safer and they also show strong activity in the treatment of diabetes. Diosgenin is such a very biologically active natural steroidal sapogenin. The research of diosgenin in the treatment of diabetes and its complications has been widely reported. This article reviews the effects of diosgenin through multiple targets and multiple pathways in diabetes and its complications which including diabetic nephropathy, diabetic liver disease, diabetic neuropathy, diabetic vascular disease, diabetic cardiomyopathy, diabetic reproductive dysfunction, and diabetic eye disease.

Study Type : Review

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