Article Publish Status: FREE
Abstract Title:

Suppression of-Induced Skin Inflammation byExtract and Its Major Constituent Eucalyptol.

Abstract Source:

Int J Mol Sci. 2019 Jul 17 ;20(14). Epub 2019 Jul 17. PMID: 31319552

Abstract Author(s):

Eun Hye Lee, Jin Hak Shin, Seon Sook Kim, Ji-Hye Joo, Eunmi Choi, Su Ryeon Seo

Article Affiliation:

Eun Hye Lee


Acne is an inflammatory skin disorder in puberty with symptoms including papules, folliculitis, and nodules.() is the main anaerobic bacteria that cause acne. It is known to proliferate within sebum-blocked skin hair follicles.activates monocytic cell immune responses to induce the expression of proinflammatory cytokines. Although the anti-inflammatory function of the() extract (LNE) on several immunological disorders have been reported, the effect of LNE in-mediated skin inflammation has not yet been explored. In the present study, we examined the ability of the LNE to modulate the-induced inflammatory signaling pathway, and evaluated its mechanism. LNE significantly suppressed the expression of-mediated proinflammatory cytokines, such as IL-1β, IL-6, and NLRP3. We also found that LNE inhibited the inflammatory transcription factor NF-κB in response to. In addition, eucalyptol, which is the main constituent of LNE, consistently inhibited-induced inflammatory signaling pathways. Moreover, LNE significantly ameliorated-induced inflammation in a mouse model of acne. We suggest for the first time that LNE hold therapeutic value for the improvement of-induced skin inflammation.

Study Type : Animal Study

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