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Abstract Title:

enhances pentobarbital-induced sleeping behaviors.

Abstract Source:

Avicenna J Phytomed. 2020 Jan-Feb;10(1):70-77. PMID: 31921609

Abstract Author(s):

Fatemeh Forouzanfar, Hamed Ghazavi, Mohammad Mahdi Vahedi, Kimia Tarrah, Zahra Yavari, Azar Hosseini, Azita Aghaee, Hassan Rakhshandeh

Article Affiliation:

Fatemeh Forouzanfar


Objective: Sleep disorders are among the most common psychiatric and medical conditions. In the present study, the hypnotic effect ofwas studied in mice

Materials and Methods: The hydro-alcoholic extract (HAE) ofand three fractions of it, namely water fraction (WF), ethyl acetate fraction (EAF), and -hexane fraction (NHF), were intraperitoneally (ip) administrated to mice 30 min before injection of sodium pentobarbital (30 mg/kg, ip). Then, 30 min after administration of HAE, motor coordination (rota-rod test) was evaluated. Besides, LDof HAE was determined and the cytotoxicity of HAE was evaluated in PC12 cells using the MTT assay.

Results: HAE 50-200 mg/kg increased the sleeping time. EAF was the only fraction which could prolong the sleep duration and decrease sleep latency. The LD50 value was 4.8 g/kg. The extract induced no cytotoxic effects in PC12 cell line.

Conclusion: The results suggested thatpotentiates pentobarbital hypnosis without causing toxic effects. Probably, its effects are mediated by the components present in EAF of this plant.

Study Type : Animal Study

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