Abstract Title:

Antimicrobial and anti-biofilm activity of tannic acid against Staphylococcus aureus.

Abstract Source:

Nat Prod Res. 2017 Aug 22:1-4. Epub 2017 Aug 22. PMID: 28826250

Abstract Author(s):

Guofeng Dong, Haiyang Liu, Xiao Yu, Xiaoxiao Zhang, Hong Lu, Tieli Zhou, Jianming Cao

Article Affiliation:

Guofeng Dong


Tannic acid, a rich of natural and process-derived phenolic compound, has been shown to be an effective antagonist against viruses and bacteria. In this study, we determined the antimicrobial activity and mechanisms of tannic acid against Staphylococcus aureus with emphasis on inhibiting effect on biofilm formation. Based on the results of time-kill assay, binding ability assay, lysozyme susceptibility assay and the transmission electron microscope, we tentatively speculated that peptidoglycan might be the target of the process that tannic acid destroy the integrity of cell wall, moreover, tannic acid could reduce the biofilm formation at sub-MIC concentrations. These results manifested that natural product tannic acid could serve as a potentially effective candidate for development of novel strategies to treat methicillin-resistant S. aureus infections.

Study Type : In Vitro Study

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