Zataria multiflora induced bronchodilatoion comparable to theophylline syrup in asthmatic patients.
Explore (NY). 2020 Jul 15. Epub 2020 Jul 15. PMID: 32709586
OBJECTIVE: The bronchodilatory effect of hydro-ethanolic extract of Z. multiflora was examined in asthmatic patients.
DESIGN: Pulmonary function tests (PFTs) were measured before and 15, 30, 60, 90, 120, 150, and 180 min after administration of the extract (20 mg/kg) in 18 asthmatics and after theophylline syrup (6 mg/kg) in 12 patients.
MAIN OUTCOME MEASURES: The extract of Z. multiflora significantly increased all PFT values, 30 to 180 min post-administration similar to the effect of theophylline (all, p<0.001). Increased PFT values due to the extract were significantly declined 180 min but the effects of theophylline were declined 150 min after administration (p<0.05 to p<0.001). Values of PFTs at baseline, 30 and 180 min after drugs administration were not singnificantly different between the extract and theophylline.
CONCLUSIONS: Z. multiflora showed a bronchodilatory effect in asthmatic patients comparable to theophylline effect but with a longer duration of action.