Article Publish Status: FREE
Abstract Title:

Swim Training Attenuates Inflammation and Improves Insulin Sensitivity in Mice Fed with a High-Fat Diet.

Abstract Source:

Int J Endocrinol. 2017 ;2017:5940732. Epub 2017 Sep 10. PMID: 29081799

Abstract Author(s):

Guangzeng Zhang, Pengfei Yu, Xiaomeng Liu

Article Affiliation:

Guangzeng Zhang


Exercise could afford multiple beneficial effects on obesity-related metabolic disorders. To address this issue, C57BL/6J mice were used to investigate the effects of 13 weeks of swim training on HFD-induced obesity and related insulin resistance and inflammation. Our results show that swim training can significantly prevent HFD-induced weight gain and increase resting energy expenditure without affecting food intake. The insulin sensitivity was enhanced in the HFD + swim group than in the HFD + sedentary group. Moreover, swim training considerably decreased serum LPS content and downregulates epididymis white adipose tissue (eWAT) expression of the inflammatory mediator Tnf-α, Il-6, and Mcp-1. In summary, 13 weeks of swim training could reverse HFD-induced metabolic disorders including insulin resistance and inflammation.

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Sayer Ji
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