Abstract Title:

20(S)-ginsenoside Rg3, a neuroprotective agent, inhibits mitochondrial permeability transition pores in rat brain.

Abstract Source:

Phytother Res. 2009 Apr ;23(4):486-91. PMID: 19003949

Abstract Author(s):

Jingwei Tian, Shumin Zhang, Guisheng Li, Zhifeng Liu, Benming Xu

Article Affiliation:

Jingwei Tian


Ginseng, the root of Panax ginseng C.A. Meyer (Araliaceae), is a well-known traditional Chinese herbal medicine. Ginsenosides, which are triterpene derivatives that contain sugar moieties, are the main active ingredients of ginseng. 20(S)-Ginsenoside Rg3, a triterpene glycoside which chemically belongs to the protopanaxadiol ginsenoside group, is effective in attenuating brain infarction after cerebral ischemia, but the detailed mechanism is not known. This study examined the effect of 20(S)-ginsenoside Rg3 on mitochondrial permeability transition pore (MPTP) in the rat brain. 20(S)-Ginsenoside Rg3 at 2-16 microm inhibited Ca(2+)- and H(2)O(2)-induced swelling of mitochondria isolated from rat brains. The addition of Ca(2+) generated reactive oxygen species (ROS) in isolated mitochondria. 20(S)-Ginsenoside Rg3 (2-16 microm) inhibited Ca(2+) induced generation of ROS. At the same time, 20(S)-ginsenoside Rg3 significantly improved mitochondrial energy metabolism, enhanced ATP levels and the respiratory control ratio. These results suggest that 20(S)-ginsenoside Rg3 inhibits the opening of MPTP by free radical scavenging action in the brain, and this implies that inhibition of MPTP may contribute to the neuroprotective effect of 20(S)-ginsenoside Rg3.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.