n/a
Article Publish Status: FREE
Abstract Title:

Analgesic and Antipyretic Activities of Ethyl Acetate Fraction Tablet ofin Animal Models.

Abstract Source:

Evid Based Complement Alternat Med. 2021 ;2021:8848797. Epub 2021 Mar 8. PMID: 33747115

Abstract Author(s):

Hilkatul Ilmi, Irfan Rayi Pamungkas, Lidya Tumewu, Achmad Fuad Hafid, Aty Widyawaruyanti

Article Affiliation:

Hilkatul Ilmi

Abstract:

Objectives: To determine the analgesic and antipyretic activities of a tablet derived fromethyl acetate fraction (AS201-01) in animal models.

Methods: The tablet derived from AS201-01 contains an equivalent of 35 mg andrographolide per tablet. Analgesic activity was determined using an acetic acid-induced writhing test on adult male mice. A writhe was recorded by a stopwatch and was defined as the stretching of the abdomen and/or stretching of at least one hind limb. For the determination of antipyretic activity, pyrexia was induced by subcutaneous injection of 15% w/v Brewer's yeast into adult male rats. Rectal temperature was monitored at 1, 2, 3, and 4 hours after treatment.

Results: The results showed that the AS201-01 tablet had analgesic and antipyretic activity. In the acetic acid-induced writhing model, AS201-01 tablet exhibited significant analgesic effect with a 66.73% reduction in writhing response at a dose of 50 mg andrographolide/kg body weight compared to the negative control group. The tablet also showed a significant antipyretic effect. The maximum antipyretic effect was observed after the third hour of administration of the AS201-01 tablet at a dose of 100 mg andrographolide/kg body weight.

Conclusion: Tablet ofethyl acetate fraction (AS201-01) exhibited analgesic and antipyretic activities.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.