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Abstract Title:

Andrographolide protects against cigarette smoke-induced lung inflammation through activation of heme oxygenase-1.

Abstract Source:

J Biochem Mol Toxicol. 2013 May ;27(5):259-65. Epub 2013 Apr 29. PMID: 23629921

Abstract Author(s):

Dongbin Yang, Weihong Zhang, Laijun Song, Fuyou Guo

Article Affiliation:

Dongbin Yang

Abstract:

This study was conducted to check whether andrographolide, a bioactive molecule isolated from Andrographis paniculata, could protect against cigarette smoke (CS)-induced lung injury through activation of heme oxygenase-1 (HO-1). Pretreatment with andrographolide (1 mg/kg body weight) markedly attenuated lung inflammation in CS-exposed mice, coupled with reduced numbers of total cells, neutrophils, and macrophages in bronchial alveolar lavage fluid (BALF) and decreased production of cytokine/chemokine into BALF. Furthermore, andrographolide pretreatment increased the expression and activation of HO-1 in the lung of CS-exposed animals. Notably, these histological and biochemical changes induced by andrographolide were blocked by prior administration of zinc protoporphyrin IX (ZnPP; 20 mg/kg body weight), a potent heme oxygenase inhibitor. Moreover, andrographolide-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3) was attenuated by ZnPP treatment in CS-exposed animals. Our data collectively demonstrate that andrographolide confers protection against CS-induced lung inflammation, partially through activation of HO-1 and STAT3.

Study Type : Animal Study

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