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Article Publish Status: FREE
Abstract Title:

Anti-Inflammatory Effect of Phytoncide in an Animal Model of Gastrointestinal Inflammation.

Abstract Source:

Molecules. 2021 Mar 26 ;26(7). Epub 2021 Mar 26. PMID: 33810618

Abstract Author(s):

Azra Memon, Bae Yong Kim, Se-Eun Kim, Yuliya Pyao, Yeong-Geun Lee, Se Chan Kang, Woon Kyu Lee

Article Affiliation:

Azra Memon

Abstract:

Phytoncide is known to have antimicrobial and anti-inflammatory properties.This study was carried out to confirm the anti-inflammatory activity of two types of phytoncide extracts from pinecone waste.We made two types of animal models to evaluate the efficacy, an indomethacin-induced gastroenteritis rat model and a dextran sulfate sodium-induced colitis mouse model.In the gastroenteritis experiment, the expression of induced-nitric oxide synthase (iNOS), a marker for inflammation, decreased in the phytoncide-supplemented groups, and gastric ulcer development was significantly inhibited (<0.05). In the colitis experiment, the shortening of the colon length and the iNOS expression were significantly suppressed in the phytoncide-supplemented group (<0.05).Through this study, we confirmed that phytoncide can directly inhibit inflammation in digestive organs. Although further research is needed, we conclude that phytoncide has potential anti-inflammatory properties in the digestive tract and can be developed as a functional agent.

Study Type : Animal Study

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