Abstract Title:

The effect of aspartame administration on oncogene and suppressor gene expressions.

Abstract Source:

In Vivo. 2007 Jan-Feb;21(1):89-92. PMID: 17354619

Abstract Author(s):

Katalin Gombos, Tímea Varjas, Zsuzsanna Orsós, Eva Polyák, Judit Peredi, Zsuzsanna Varga, Ghodratollah Nowrasteh, Antal Tettinger, Gyula Mucsi, István Ember

Article Affiliation:

Faculty of Medicine, Institute of Public Health University of Pécs, Pécs, Hungary. katalin_gombos@yahoo.com


BACKGROUND: Aspartame (L-phenylalanine N-L-alpha-aspartyl-1-methyl ester) is an artificial sweetener with widespread applications. Previously published results have shown that among rats receiving aspartame a significant increase of lymphoreticular neoplasms, brain tumours and transitional cell tumours occurred. The aim of our short-term experiment was to investigate the biological effect of aspartame consumption by determining the expressions of key oncogenes and a tumour suppressor gene. MATERIALS AND METHODS: After one week per os administration of various doses of aspartame to CBA/CA female mice, p53, c-myc, Ha-ras gene expression alterations were determined in individual organs. RESULTS: The results showed an increase in gene expressions concerning all the investigated genes especially in organs with a high proliferation rate: lymphoreticular organs, bone-marrow and kidney. CONCLUSION: Aspartame has a biological effect even at the recommended daily maximum dose.

Study Type : Animal Study
Additional Links
Problem Substances : Aspartame : CK(216) : AC(77)

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