Article Publish Status: FREE
Abstract Title:

Bioactive chromone constituents fromalleviate pain and inflammation.

Abstract Source:

J Pain Res. 2018 ;11:95-102. Epub 2017 Dec 28. PMID: 29343985

Abstract Author(s):

Ajmal Khan, Sadia Naz, Umar Farooq, Muhammad Shahid, Irfan Ullah, Iftikhar Ali, Abdur Rauf, Yahia Nasser Mabkhot

Article Affiliation:

Ajmal Khan


Background: L. has been widely studied for its beneficial effect in inflammatory and pain conditions. The present study describes the isolation of two new bioactive chromone constituents fromand their in vivo evaluation for anti-inflammatory and antinociceptive activities.

Methods: Two new chromone derivatives, namely, methyl 3-(2-(5-hydroxy-6-methoxy-4-oxo-4H-chromen-2-yl)ethyl)benzoateand 3-(1-hydroxy-2-(5-hydroxy-6-methoxy-4-oxo-4H-chromen-2-yl)ethyl)benzoic acidwere isolated fromand their structures were determined through various spectroscopic techniques including mass spectrometry, UV, IR, 1H NMR, 13C NMR, and two-dimensional-NMR like correlation spectroscopy and heteronuclear multiple bond correlation techniques. The isolated compounds (-) were tested for their prospective antinociceptive activity in acetic acid-induced abdominal constriction assay and anti-inflammatory activity in the carrageenan-induced paw edema assay in mice.

Results: Significant attenuation (<0.001) of tonic visceral nociception was demonstrated by compoundandat doses of 50 and 100 mg/kg. At similar doses, these compounds (-) also showed potent amelioration (<0.001) of carrageenan-induced paw swelling.

Conclusion: The isolated chromone derivatives (-) fromare able to alleviate nociception and inflammation and the findings corroborated thatmay be used as a potential source of antinociceptive and anti-inflammatory candidates.

Study Type : Animal Study

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