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Article Publish Status: FREE
Abstract Title:

Bisphenol-S and Bisphenol-F alter mouse pancreaticβ-cell ion channel expression and activity and insulin release through an estrogen receptor ERβ mediated pathway.

Abstract Source:

Chemosphere. 2021 Feb ;265:129051. Epub 2020 Nov 20. PMID: 33250229

Abstract Author(s):

Laura Marroqui, Juan Martinez-Pinna, Manuel Castellano-Muñoz, Reinaldo S Dos Santos, Regla M Medina-Gali, Sergi Soriano, Ivan Quesada, Jan-Ake Gustafsson, José A Encinar, Angel Nadal

Article Affiliation:

Laura Marroqui

Abstract:

Bisphenol-S (BPS) and Bisphenol-F (BPF) are current Bisphenol-A (BPA) substitutes. Here we used pancreaticβ-cells from wild type (WT) and estrogen receptor β (ERβ) knockout (BERKO) mice to investigate the effects of BPS and BPF on insulin secretion, and the expression and activity of ion channels involved in β-cell function. BPS or BPF rapidly increased insulin release and diminished ATP-sensitive K(K) channel activity. Similarly, 48 h treatment with BPS or BPF enhanced insulin release and decreased the expression of several ion channel subunits in β-cells from WT mice, yet no effects were observed in cells from BERKO mice. PaPE-1, a ligand designed to preferentially trigger extranuclear-initiated ER pathways, mimicked the effects of bisphenols, suggesting the involvement of extranuclear-initiated ERβ pathways. Molecular dynamics simulations indicated differences in ERβ ligand-binding domain dimer stabilization and solvation free energy among different bisphenols and PaPE-1. Our data suggest a mode of action involvingERβ whose activation alters three key cellular events in β-cell, namely ion channel expression and activity, and insulin release. These results may help to improve the hazard identification of bisphenols.

Study Type : Animal Study

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