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Article Publish Status: FREE
Abstract Title:

Crocins fromL. in the Management of Hyperglycemia. In Vivo Evidence from Zebrafish.

Abstract Source:

Molecules. 2020 Nov 10 ;25(22). Epub 2020 Nov 10. PMID: 33182581

Abstract Author(s):

Eleni Kakouri, Adamantia Agalou, Charalabos Kanakis, Dimitris Beis, Petros A Tarantilis

Article Affiliation:

Eleni Kakouri

Abstract:

Diabetes mellitus is a disease characterized by persistent high blood glucose levels and accompanied by impaired metabolic pathways. In this study, we used zebrafish to investigate the effect of crocins isolated fromL., on the control of glucose levels and pancreaticβ-cells. Embryos were exposed to an aqueous solution of crocins and whole embryo glucose levels were measured at 48 h post-treatment. We showed that the application of crocins reduces zebrafish embryo glucose levels and enhances insulin expression. We also examined whether crocins are implicated inthe metabolic pathway of gluconeogenesis. We showed that following a single application of crocins and glucose level reduction, the expression of(), a key gene involved in glucose metabolism, is increased. We propose a putative role for the crocins in glucose metabolism and insulin management.

Study Type : Animal Study

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