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Abstract Title:

Date fruit extract is a neuroprotective agent in diabetic peripheral neuropathy in streptozotocin-induced diabetic rats: a multimodal analysis.

Abstract Source:

Oxid Med Cell Longev. 2011 ;2011:976948. Epub 2011 Dec 1. PMID: 22191015

Abstract Author(s):

Nasser Zangiabadi, Majid Asadi-Shekaari, Vahid Sheibani, Mandana Jafari, Mohammad Shabani, Ali Reza Asadi, Hale Tajadini, Morteza Jarahi

Article Affiliation:

Nasser Zangiabadi

Abstract:

BACKGROUND: To study the effects of an aqueous extract of date fruit (Phoenix dactylifera L. Arecaceae) diet on diabetic polyneuropathy (DPN) in streptozotocin- (STZ-) induced diabetic rats.

METHODS: The effects of a date fruit extract (DFE) diet on diabetic neuropathy in STZ-induced diabetic rats were evaluated and compared with a nondiabetic control group, diabetic control group (sham), and vehicle group with respect to the following parameters: open field behavioral test, motor nerve conduction velocity (MNCV), and morphological observations.

RESULTS: In the model of STZ-induced of diabetic neuropathy, chronic treatment for 6 weeks with DFE counteracted the impairment of the explorative activity of the rats in an open field behavioral test and of the conduction velocity of the sciatic nerve (MNCV). In addition, pretreatment with DFE significantly reversed each nerve diameter reduction in diabetic rats.

CONCLUSION: DFE treatment shows efficacy for preventing diabetic deterioration and for improving pathological parameters of diabetic neuropathy in rats, as compared with control groups.

Study Type : Animal Study

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