Abstract Title:

Dietary grape-seed procyanidins decreased postweaning diarrhea by modulating intestinal permeability and suppressing oxidative stress in rats.

Abstract Source:

J Agric Food Chem. 2011 Jun 8 ;59(11):6227-32. Epub 2011 May 6. PMID: 21534629

Abstract Author(s):

Peixia Song, Ruoji Zhang, Xiaoxiao Wang, Pingli He, Lulin Tan, Xi Ma

Article Affiliation:

Peixia Song


This study was conducted to evaluate the effects of grape-seed procyanidins in controlling weaning diarrhea using a rat model. Weaned rats were fed either the basal diet or basal diet supplemented with either 250 mg/kg grape-seed procyanidins or 2000 mg/kg ZnO. Treated rats had better performance with a reduced incidence of diarrhea (P<0.05). Both ZnO and grape-seed procyanidins significantly reduced urinary lactulose to mannitol ratios (P<0.05) and enhanced the mRNA and protein expression of the intestinal mucosal tight junction proteins Ocln/ZO-1 (P<0.05). Grape-seed procyanidins increased the activities of SOD, GSH-Px, and GSH while decreasing the level of MDA in the intestinal mucosa (P<0.05). Furthermore, an in vitro investigation revealed that supplementation with grape-seed procyanidins in IEC-6 intestinal epithelial cells significantly enhanced the expression of Ocln/ZO-1 under H(2)O(2)-induced oxidative stress. Collectively, these results indicate that grape-seed procyanidins have the potential to prevent weaning diarrhea by reducing intestinal permeability and improving antioxidant indices.

Study Type : Animal Study

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