Abstract Title:

Dietary Whey Protein Decreases Food Intake and Body Fat in Rats.

Abstract Source:

Obesity (Silver Spring). 2011 Feb 17. Epub 2011 Feb 17. PMID: 21331067

Abstract Author(s):

June Zhou, Michael J Keenan, Jack N Losso, Anne M Raggio, Li Shen, Kathleen L McCutcheon, Richard T Tulley, Marc R Blackman, Roy J Martin

Article Affiliation:

1] Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA [2] Louisiana State University Agricultural Center, Baton Rouge, Louisiana, USA [3] Research Service, Veterans Affairs Medical Center, Washington, DC, USA.

Abstract:

We investigated the effects of dietary whey protein on food intake, body fat, and body weight gain in rats. Adult (11-12 week) male Sprague-Dawley rats were divided into three dietary treatment groups for a 10-week study: control. Whey protein (HP-W), or high-protein content control (HP-S). Albumin was used as the basic protein source for all three diets. HP-W and HP-S diets contained an additional 24% (wt/wt) whey or isoflavone-free soy protein, respectively. Food intake, body weight, body fat, respiratory quotient (RQ), plasma cholecystokinin (CCK), glucagon like peptide-1 (GLP-1), peptide YY (PYY), and leptin were measured during and/or at the end of the study. The results showed that body fat and body weight gain were lower (P<0.05) at the end of study in rats fed HP-W or HP-S vs. control diet. The cumulative food intake measured over the 10-week study period was lower in the HP-W vs. control and HP-S groups (P<0.01). Further, HP-W fed rats exhibited lower N(2) free RQ values than did control and HP-S groups (P<0.01). Plasma concentrations of total GLP-1 were higher in HP-W and HP-S vs. control group (P<0.05), whereas plasma CCK, PYY, and leptin did not differ among the three groups. In conclusion, although dietary HP-W and HP-S each decrease body fat accumulation and body weight gain, the mechanism(s) involved appear to be different. HP-S fed rats exhibit increased fat oxidation, whereas HP-W fed rats show decreased food intake and increased fat oxidation, which may contribute to the effects of whey protein on body fat.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.