Abstract Title:

Effect of rice-expressed amyloidβ in the Tg2576 Alzheimer's disease transgenic mouse model.

Abstract Source:

Vaccine. 2011 Aug 26 ;29(37):6252-8. Epub 2011 Jul 2. PMID: 21726591

Abstract Author(s):

Jun Nojima, Azusa Maeda, Sho Aoki, Satoshi Suo, Dai Yanagihara, Yuichiro Watanabe, Taiji Yoshida, Shoichi Ishiura

Article Affiliation:

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan.


One of the main hallmarks of Alzheimer's disease (AD) is senile plaques composed of amyloidβ (Aβ). We developed a new edible vaccine: rice expressing GFP-Aβ42. In a previous report, we described the production of anti-Aβ antibodies in B6 mice fed Aβ rice mixed with cholera toxin B subunit (CTB). In this report, we investigated whether Aβ rice had therapeutic effects in the Tg2576 ADmodel mice. The anti-Aβ antibody titer was increased and levels of intracerebral Aβ (soluble and insoluble) and serum Aβ decreased. Because the value of IgG1/IgG2a in the Aβ feeding group was>1, immunization via Aβ rice may induce a non-inflammatory Th2 reaction. We also found that the Aβ vaccine improved memory, as assessed in a Y-maze test. The number of arm entries in the Y-maze test was lower in the Aβ feeding group than in the control group. These results suggest that the new edible vaccine Aβ ricemay have therapeutic effects in AD.

Study Type : Plant Study
Additional Links
Additional Keywords : Edible Vaccines : CK(17) : AC(0)

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